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Candidal balanoposthitis in type 2 diabetic patients: symptoms, clinical event and treatment DOI: 10.29188/2222-8543-2022-15-1-170-176
- Slesarevskaya M.N. — Dr. Sc., senior researcher of the Research Center of Urology, Research Institute for Surgery and Emergency Medicine, I.P. Pavlov First Saint Petersburg State Medical University; Saint-Petersburg, Russia; https://orcid.org/0000-0002-4911-6018
- Kuzmin I.V. — Dr. Sc., professor of the Department of Urology, I.P. Pavlov First St. Petersburg State Medical University; Saint-Petersburg, Russia; https://orcid.org/0000-0002-7724-7832
- Kraeva L.A. – Dr. Sc., head of the Laboratory of Medical Bacteriology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology; 14, Mira str., St. Petersburg, Russian Federation; professor of the Department of Microbiology, Military Medical Academy named after S.M. Kirov; Saint-Petersburg, Russia; https://orcid.org/0000-0002-9115-3250
666 Introduction. The proportion of candidal balanoposthitis is 30-35% of all forms of infectious balanoposthitis. Diabetes mellitus is one of the main risk factors for the development of the disease.
The purpose of the study was to conduct a comparative assessment of the effectiveness of clotrimazole 1% and 2% cream in the complex treatment of patients with candidal balanoposthitis on the background of diabetes mellitus.
Materials and methods. iabetes mellitus aged 20 to 77 years (average 55.2±12.7 years) were included in the study. The patients were divided into two groups: the main group (n=16) and the comparison group (n=15). All patients on the 1st day of treatment were prescribed the antimycotic drug fluconazole 150 mg once for the treatment of candidal balaponostitis. For local therapy 2% clotrimazole cream was used in patients of the main group and 1% clotrimazole cream was used in patients of the comparison group, cream was applied to the skin of the glans penis and foreskin 2 times a day until the symptoms resolved.
Results. Starting from 3-4 days of treatment patients noted a decrease in the intensity of symptoms of candidal balanoposthitis - a decrease in the severity of itching and burning in the glans penis and foreskin, as well as the amount of discharge from the prepuce. The clinical efficacy of therapy was higher in patients of the main group compared with patients from the comparison group. The disappearance of clinical manifestations of the disease was observed in patients of the main group at 7.06±1.57 days from the start of treatment, in the comparison group - at 8.13±1.68 days (p=0.041). On average the duration of treatment until the elimination of clinical manifestations of the disease in patients of the main group was 13.2% less than in the comparison group. The fastest cure occurred in patients with erythematous and papular forms of the disease, somewhat more slowly - with exudative and erosive forms.
Conclusions. Treatment of candidal balanoposthitis in patients with diabetes mellitus requires the appointment of systemic and local antifungal therapy. The use of 2% clotrimazole cream showed high efficacy and good tolerance and can be recommended for use in a wide clinical practice.
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