Number №2, 2013 - page 116-120

Combination therapy of the urogenital infections in men

Popov S.V.

Nowadays, the growth of the urogenital infections frequency could be visible because of the introduction of the screening programs and utilization of the high-sensitive diagnostic methods and also because of the full registration of the primary cases.

Clinical significance of the sexuallytransmitted diseases (STD) in young men is a consequence of the high transmission and acquisition risks of HIV-infection and the possibility of the development of the chronic diseases of genitalia, complicated in some cases by infertility. Modern antibiotics therapy, which is effective against the atypical intracellular microorganisms – causative agents of the non-gonococci urethritis – is performed using the medications groups of macrolides, tetracyclines and fluoroquinolones. Nitroimidazoles are still the only group for treatment of the patients with trichomoniasis. Of special interest is now a combination medication for mixed infection, which recently entered the market, Combyflox®, the combination of the ofloxacin 200 mg and ornidazole 500 mg in one tablet. This new drug has a number of merits: a high activity against Chlamydia, Mycoplasma and Trichomonas, ability to create high and stable concentrations in the tissues, long half-life period and good tolerance profile. These merits make this medication a good alternative for treatment of men with STD.

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