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Determination of the chemical composition of urinary stones in vivo by the profile of nutrient consumption DOI: 10.29188/2222-8543-2020-13-4-50-56
For citation:
Prosyannikov M.Yu., Golovanov S.A., Konstantinova O.V., Voytko D.A., Anokhin N.V., Sivkov A.V., Apolikhin O.I. Determination
of the chemical composition of urinary stones in vivo by the profile of nutrient consumption. Experimental and clinical urology 2020(4):50-56, https://doi.org/10.29188/2222-8543-2020-13-4-50-56
Prosiannikov M.Yu. – PhD, Head of Department of urolithiasis of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; Moscow, Russia; https://orcid.org/0000-0003-3635-5244.
Golovanov S.A. – Dr. Sc., head of scientific Laboratory Department of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation; Moscow, Russia; https://orcid.org/0000-0002-6516-4730
Konstantinova O.V. – Dr. Sc., Chief Researcher at the Department of urolithiasis of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; Moscow, Russia; https://orcid.org/0000-0002-2214-7543
Voytko D.A. – PhD, researcher at the research Institute of urology and interventional radiology. N.A. Lopatkina-branch of the Federal state budgetary institution «NMIC of radiology» of the Ministry of health of Russia; Moscow, Russia
Anokhin N.V. – PhD, Researcher of the Department of urolithiasis of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; Moscow, Russia; https://orcid.org/0000-0002-4341-4276
Sivkov A.V. – PhD, Deputy Director on scientific work of N. Lopatkin Research Institute of urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of Ministry of health of Russian Federation; Moscow, Russia; https://orcid.org/0000-0001-8852-6485
Apolikhin O. I. – Dr. Sc., professor, Director of N. Lopatkin Research Institute of urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of Ministry of health of Russian Federation; Moscow, Russia; https://orcid.org/0000-0003-0206-043X
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Introduction. Сurrently, existing methods for determining the chemical composition of the stone in vivo do not have the necessary accuracy. In this regard, the development of methods for high-precision determination of the chemical nature of urinary stones using modern technologies is relevant for modern urology.
Materials and methods. 72 patients with urolithiasis who were treated at the Institute of urology and interventional radiology. N.A. Lopatkin – a branch of the Federal state budgetary institution «NMIC of radiology» of the Ministry of health of Russia, along with standard methods of examination, performed the determination of the chemical composition of urinary stones using infrared spectroscopy. Urinary stones were classified according to the predominant mineral component into six main types (calcium-oxalate, uric acid, calcium phosphate, magnesium-ammonium-phosphate, urate–ammonium and mixed), as well as determining the nutrition stereotype for 25 nutrients using an electronic questionnaire. The classification model was built using the tools of a modern set of Data mining methods-IBM SPSS Modeler 18.0 (IBM Corporation, USA).
Results. the data set includes the results of the survey of pattern of food and chemical composition analysis of urinary stones on the basis of which a model was produced, allowing high-precision to predict in vivo chemical type of urinary stones. The constructed machine-learning model (C5.0 algorithm) has high predictive accuracy (98.6-100%), specificity (98.2-100%), and sensitivity (100% for the main types of stones and 75.0% for mixed ones).
Conclusions. the Developed method for determining the chemical composition of urinary calculus in vivo based on the indicators of the patients nutrition stereotype has a high specificity, sensitivity and accuracy, which allows using this prognostic model in clinical practice.
5-year impact factor of Russian science citation index from 15.01.2020 - 0,723
10-year H-index 21
Included in the Russian Science Citation Index (RSCI)
ISSN print 2222-8543 ISSN online 2712-8571
The journal is included in the List of Russian peer-reviewed scientific journals which should publish the main scientific results of dissertations for the degrees of Doctor and PhD of sciences
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