Relevance. In males with sexual disorders hyperprolactinemia is determined in 0,4-11% of cases, and in some studies achieves 20%, due to which assessment of the prolactin level in blood is an important part of erectile dysfunction diagnostics. Objective. To study frequency of occurrence and general clinical presentation of hyperprolactinemia in patients with erectile dysfunction (ED). Materials and methods. We have examined a big group of patients with ED of different etiology. Hyperprolactinemia was detected in 69 (9%) patients of general group. Retrospectively in these patients with hyperprolactinemia clinical presentation was dominantly of an endocrine character. Decrease or absence of libido in 58 (84%), gynecomastia - 12 (17,4%), galactorrhea - 2 (2,9%), a rare beard growth were observed in 4 (5,8%) patients. Prolactin level in blood serum was in range 360 - 8000 mU/l (average 1200 mU/l, normal values < 360). Hypophysis visualization was performed in case of prolactin level increase. CT (62%) or MRI (38%) revealed pituitary macroadenomas in 30 (43,5%) patients, pituitary microadenomas in 21 (30,4%) patients and did not reveal any pathologic changes in 18 (26,1%) patients. 20 patients (28,9%) with hyperprolactinemia had low levels of testosterone. During the treatment (bromocriptine 1,25 mg 2-3 times daily, gradually increasing the dose of 5-10 mg / day for 1-2 months) we found that at the background of hyperprolactinemia erectile function is inhibited regardless of androgen status.
Conclusion. Thus we can say that evaluation of prolactin concentration in blood is an important part in diagnostics of ED etiology and must be performed in all patients complaints of erection quality reduce.
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