This article is devoted to the description of the method of extracorporeal indirect electrochemical oxidation (EIEBO) in patients with infectious inflammatory complications and grade I endotoxicosis. The distinguishing feature of the EIEBO from the adopted intracorporeal method of oxidation is that blood is being processed using 0.06% solution of the sodium hypochlorite (SH) within the venous extracorporeal line, created using special equipment. The dose of the 0.06% SH solution, which is used for one seance of the EIEBO, is 0.75 mg/kg. Two liters of patient’s blood are being processed. catheterization of the central vein is not necessary during EIEBO and the latter could be performed in the ambulatory setting.