When using the method of gas chromatography-mass-spectrometry of urine microbiota and urinary stones presented obligate, facultative and transient microorganisms. The total bacterial load of patients with urolithiasis, especially with systemic forms of the disease, is much higher than in representatives of the control group.

One of the main stabilizers of the colloidal system of urine is the Tamm-Horsfall protein (THP). When the microbiota of urine changes and increase the total bacterial load it leads to a violation of the structure of the THP with formation of megamolecular complexes. Noted that patients with urolithiasis size megamolecular complexes in 10 times more, than at healthy persons in the control group.

In the complex of measures for the prevention and metaphylaxis of urolithiasis, it is advisable to use antimicrobial therapy with uroseptics, which will affect the quantitative and qualitative indicators of the microbial spectrum, as well as improve the stability of the colloidal properties of urine.

Author declare lack of the possible conflicts of interests