18+

 

Number №4, 2017 - page 96-100

Interstitial cystitis – pathogenesis, diagnosis and treatment strategies: an update. part 1 – pathogenesis

Mirkin Ya.B., Karapetyan A.V., Shumov S.Yu.
1718

Interstitial cystitis/Bladder pain syndrome (IC/BPS) is the severe pathologic condition with strong impact on quality of life. Current treatment options are not completely effective as far as IC/BPS has very complex pathogenesis, which include such factors as:

  1. Urothelium’s impairment
  2.  Non-bacterial inflammation in the suburothelium with mast cells activation.
  3. Sensitization of peripheral nervous endings.
  4. Pelvic organ’s cross-talking.
  5.  Pelvic floor muscles overactivity.
  6. Central sensitization.

That’s why correct therapeutic strategies should involve all those factors.

Authors declare lack of the possible conflicts of interests.

AttachmentSize
Download1.34 MB
intestial cystitis, glycosaminoglycan layer, chronic pelvic pain syndrome, painful bladder syndrome, urothelium

Readera - Социальная платформа публикаций

Crossref makes research outputs easy to find, cite, link, and assess