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Number №3, 2023 - page 38-49

Intrarenal and central hemodynamics after Grade I-III kidney injury: is there a direct cause-and-effect relationship with posttraumatic arterial hypertension? DOI: 10.29188/2222-8543-2023-16-3-38-49

For citation:

 Chiglintsev K.A., Zyrianov A.V., Chiglintsev A.Yu. Intrarenal and central hemodynamics after Grade I-III kidney injury: is there a direct cause-and-effect relationship with posttraumatic arterial hypertension? Experimental and Clinical Urology 2023;16(3):38-49; https://doi.org/10.29188/2222‑8543‑2023‑16‑3‑38‑49

Chiglintsev K.A., Zyrianov A.V., Chiglintsev A.Yu.
Information about authors:
  • Chiglinczev K.A. – PhD., associate professor, department of urology, nephrology and transplantology of the Federal State Budgetary Edicational Institution of Higher Edication «Ural State Medical University» of the Ministry of Health of the Russian Federation; Yekaterinburg, Russia; RSCI Author ID 1108166; https://orcid.org/0000‑0001‑9888‑688X
  • Zyrianov A.V. – Dr. Sci., head of the department of urology, nephrology and transplantology of the Federal State Budgetary Edicational Institution of Higher Edication «Ural State Medical University» of the Ministry of Health of the Russian Federation; Yekaterinburg, Russia; RSCI Author ID 328820; https://orcid.org/0000‑0001‑8105‑7233
  • Chiglinczev A.Yu. – Dr. Sci., deputy chief physician Medico-diagnostic center «Arnika»; Chelyabinsk, Russia; RSCI Author ID 70376; https://orcid.org/0000‑0003‑4704‑7933
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Introduction. Mechanical kidney injuries lead to renal dysfunction and vasospastic reaction, resulting in adaptive reactions of the organism, with the possibility of formation of secondary arterial hypertension.

Purpose of the study: to determine the types of central gemodynamics, intrarenal blood flow characteristics, correlation interrelations of indices and to estimate the risks of secondary posttraumatic arterial hypertension development after Grade I-III kidney injury.

Material and methods. Systemic hemodynamic parameters with identification of blood circulation type and intrarenal hemodynamic parameters were studied in 196 male victims in the posttraumatic period, the control group consisted of 30 men. During statistical processing Pearson correlation coefficients (r) and linear regression coefficient of determination (r2) were additionally calculated.

Results. After kidney injury, the organ blood flow velocity was increased from 12,5% to 31,2%, resistance index (RI) increased from 4,7% to 44,8%, and pulsation index (PI) decreased from 9,2% to 41,2%. The indices of intrarenal vascular resistance were in negative from very strong to medium strength correlation with the parameters of systemic hemodynamics in the following gradation structure by decreasing strength: total peripheral resistance → diastolic blood pressure → systolic blood pressure → mean arterial pressure → stroke volume → cardiac index → minute volume of blood. Hypokinetic type steadily prevailed in central hemodynamics, the share of eukinetic type increased, and hyper-kinetic type of hemodynamics remained at a constant level.

Conclusion. After kidney injury of non-critical severity the ascertained parameters of systemic and organ hemodynamics do not possess predictive power for realization of direct causal relationship in the development of secondary renoparenchymatous arterial hypertension.

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kidney injury; linear renal blood flow velocity; intrarenal vascular resistance indices; types of central hemodynamics; adaptation strategies; secondary arterial hypertension

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