Introduction. Prevention of relapse of calcium-oxalate urolithiasis is challenging. Diet as the first stage of prevention does not always allow to achieve remission. Herbal preparations are widely used as alternative treatment. One of these drugs is Oxalit – a biologically active complex.

Purpose. The evaluation of the impact of the «Oxalit» complex on metabolic parameters in patients with urolithiasis, and the determination of the possibilities of its use in the treatment of patients with calcium-oxalate urolithiasis.

Materials and methods. A clinical study of the biologically active complex «Oxalit» was conducted. The study involved 60 patients with urolithiasis: the treatment arm included 30 patients who received «Oxalit» for 90 days with diet recommendations. The control arm consisted of 30 patients with urolithiasis received only diet recommendations for 90 days.

Results and discussion. In the treatment group (Oxalit), a 2.4-fold decrease in renal excretion of oxalates and an increase in urinary excretion of magnesium by 53.4% were noted. The level of hematuria, leukocyturia and proteinuria was almost 3 times lower. However, urinary glucose excretion in- creased. There were no statistical changes in renal daily excretion of sodium, inorganic phosphates, citrates, urea, chlorine, bilirubin, and urine output.

Conclusions. The biologically active complex «Oxalit» can be recommended in the treatment of calcium-oxalate urolithiasis as an anti-relapse drug.

Conflict of interest. The authors declare no conflict of interest.