Бебешко Е.В.

Uremic toxins accumulate in patients with chronic kidney disease. These molecules may deteriorate the biochemical and physiological dysfunctions that define the uremic syndrome. Earlier studies concentrated on small water soluble and large middle molecules. However, the focus of the clinicians is shifting toward protein-bound uremic toxins recently. Protein-bound uremic toxins, including many kinds of different toxins, have been neglected for a long time and its clinical importance has been demonstrated in recent years.

Renal replacement therapy is vital man­agement of renal failure. Hemodialysis is a hardware-based method of blood clearance, spread widely because of its efficacy. Renal failure morbidity is 150 - 200 cases per 1 million of population yearly. In 2001 in Russian Federation there were 7148 dialysis patients, in 2008 - 21357.