Григорьев М.Э.

Widely used detection of the prostatic specific antigen (PSA) to the growth of the prostate biopsies being performed; introduction of the age-related normal values of PSA led to growth of the number of unjustified biopsies. As a result of this the constant need in the new prostate cancer biomarkers is obvious. PCA3 – is a non-coding mRNA, which is expressed exclusively by the prostate cells.

Article is dedicated to analysis of results of open multicentre research of using doxazosin in combination with Indigal in patients with BPH. Research is held in 8 clinical centre, with 100 patients participating. The subjects for study were efficiency and safety of oral taking of doxazosin in combination with Indigal during a period of six months, long-term follow up was 6 months. Patients took two capsules of Indigal twice a day and doxazosin 2–8 mg, starting with 2 mg with following dose titration. Four visits to doctor were planned.