Константинова О.В.

We have investigated the relationship between unilateral and bilateral urolithiasis and single nucleotide polymorphisms (SNP) in known urolithiasis-related genes in Russian population. Overall, 115 adult patients from the Central Russia – 71 male patients (61.7%) and 44 female patients (38.3%) were included as study group, and 188 healthy adults as control group (from the corresponding region). The mean age of the study group patients was 44.5±14 years. Among the patients of study group 41 had unilateral and 74 bilateral urolithiasis.

We have carried out the retrospective analysis of 1355 medical records of the patients with urolithiasis referred to the ambulance of National Scientific Institute of Urology in a period of 1 year. Chi-square statistical test was used for analysis of data. The most visited months of the year were April and November (spring-autumn period). The minimal and maximal age of the patients (based on the analysis of 923 patients) was 8 months and 83 years. Female patients were dominating among adult patients.

In this study we have evaluated the link between the urolithiasis and burdened familial history and single nucleotide polymorphisms (SNP) of the candidate genes without familial anamnesis. We have investigated 125 adult patients with urolithiasis (main study group) from Central Russia and 188 healthy adults from the same region (control group).

Operative treatment in patients with large and staghorn urinary stones of anatomically or functional solitary kidney is one of the complicated problems in urology. Literature review shows that extracorporeal shockwave lithotripsy (ESWL) as monotherapy has low efficacy in patients with this form of urolithiasis and its role could be described as amplification of other modalities, for example, in the combination treatment with transurethral and percutaneous manipulations.

The study of the genetic risk factors in the development of the urolithiasis was undertaken in russian population. One hundred and one patients were investigated as study group and 393 healthy patients were used as control group. All patients were from Central Russia. Among the patients of the study group 32 had healthy relatives (17 male and 15 female patients) and 69 – had close relatives with urolithiasis (44 men and 25 women).

In this study we have investigated 54 patients with urolithiasis, 21 female and 33 male patients with the age range of 21-74 year. Sixteen women had calcium-oxalate stones, five – mixed stones with calcium-phosphate component – carbonapathite. Twenty five male patients had calcium-oxalate stones, eight – mixed with the presence of carbonapathite.

The social significance of urolithiasis in recent years, finds a new urgency to the global changes in the health of the world population. Tendency of progressive increase in the prevalence of the urolithiasis is obvious, which requires the development of highly efficient methods of prevention and minimally invasive methods of treatment. In recent years there has been a multi-disciplinary approach to the study of the urolithiasis due to principles of evidence based medicine.

The stone disease is one of most widespread urology disease in the world and Russia. The recurrence rate is high despite the new noninvasive methods of diagnosis and treatment. Phytotherapy, containing essential oils and terpens, is widely used in patients with stone disease. Rowatinex is based on the terpens combination.

The research was done in State Research Institute of Urology during 2,5 months named: “ Results of the Rowatinex usage in patients with renal stone disease”.

In scientific research institute of urology of Russian health care department unified recommendations schemes of urate, calcium-oxalate and calcium-phosphate calculi formation prophylaxis were developed and already used for many years. They reflect tactics of management of stated groups of patients, contain information of chemical structure of calculi removed or drawn off by itself, disorders of lithogenous compounds exchange, which were the basement of scheme development. To evaluate the efficacy of long-term outpatient treatment of patients due to these sch