инфравезикальная обструкция

In this experimental work on 28 female inbreed rats we have studied the action of the complex of anti-ischemic medications (alpha-tocopherol, trental, mexidol and diltiazem in a daily dosage 10 mg/kg, 4 mg/kg, 5 mg/kg and 2 mg/kg, correspondingly) and alpha-adrenoblocker doxazosin in a daily dosage 0.05 mg/kg with the background of the modelled infravesical obstruction via the dosed compression of the infravesical urethra.

Effects of botulinum toxin injection into detrusor on autonomic regulation were studied in normal and after 1 month of infravesical obstruction modeling. Investigations were made in acute experiments during infusion cystometry, in which synchronous registration was performed of detrusor pressure and bladder impedance with highly sensitive soft and hardware complex (“Biola”).

97 patients with voiding disturbances underwent treatment, 27 had a hyporactive bladder(15 male, 12 female) and 70 male with infravesical obstruction. Infravesical obstruction in 36 patients was caused by chronic prostatitis, in 34 by BPH. All patients were subscripted for prostate peptides (uroprost) in suppositorium once a day for 20 days. 66.6% of patients with detrusor hypoactivity considered treatment results as high or moderate. Qmax improvement for 29.4% meanly was mentioned.