Interstitial cystitis – pathogenesis, diagnosis and treatment strategies: an update. part 1 – pathogenesis

Interstitial cystitis/Bladder pain syndrome (IC/BPS) is the severe pathologic condition with strong impact on quality of life. Current treatment options are not completely effective as far as IC/BPS has very complex pathogenesis, which include such factors as:

1. Urothelium’s impairment
2.  Non-bacterial inflammation in the suburothelium with mast cells activation.
3. Sensitization of peripheral nervous endings.
4. Pelvic organ’s cross-talking.
5.  Pelvic floor muscles overactivity.
6. Central sensitization.

That’s why correct therapeutic strategies should involve all those factors.

Authors declare lack of the possible conflicts of interests.