A retrospective analysis of antiulcer prophylaxis efficacy, based on the results of 8346 surgical interventions on the organs of the urogenital systemand 1960 esophagogastroduodenoscopies. A comparative analysis of the efficacy of application of H2 – receptor blockers of II and III generation proton pump blockers in anti-ulcer prophylaxis. With small volume urological surgeries antiulcer prophylaxis should be done only to patients with concomitant gastric ulcer and duodenal ulcer. It is desirable to prescribe oral forms of H2 histamine receptor blockers or proton pump blockers.

The total antiulcer prophylaxis is only appropriate in nephrectomy and partial nephrectomy due to tumors, radical prostatectomy and cystectomy. Parenteral H2 histamine receptor blockers are indicated in patients suffering from peptic ulcer and duodenal ulcers, with interventions such as open surgery on the kidney and upper urinary tract due to staghorn nephrolithiasis, extended ureteral stricture, malignant neoplasms.

Prescription of expensive parenteral proton pump blockers suitable only for patients who are assumed to undergo radical prostatectomy, radical cystectomy, intestinal neobladder plastics, etc., and the most seriously ill patients after massive blood loss with persistent systemic hemodynamic disorders regardless of the amount the surgery.