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Characteristics of prostate cancer detected during primary (systematic) and repeated prostate biopsy and its assessment after radical prostatectomy DOI: 10.29188/2222-8543-2021-14-4-30-36
- Chibichian M.B. – Dr.Sc. (Med), Assoc.Prof. (Docent); Assoc. Prof., Dept. of Urology and Human Reproductive Health with Pediatric Urology and Andrology Course, Rostov State Medical University; Rostov-on-Don, Russia; https://orcid.org/0000-0003-2765-7910
- Avetyan A.V. – postgraduate student, Dept. of Urology and Human Reproductive Health (with Pediatric Urology and Andrology Course), Rostov State Medical University; Rostov-on-Don, Russia; https://orcid.org/0000-0001-7748-0039
- Belousov I.I. – Dr. Sc., Professor, Dept. of Urology and Human Reproductive Health (with Pediatric Urology and Andrology Course), Rostov State Medical University; Rostov-on-Don, Russia; https://orcid.org/0000-0003-0674-9429
- Lapteva T.O. – a pathologist of the highest category, head of the pathological department of the FSBI RNIOI of the Ministry of Health of Russia; Rostov-on-Don, Russia; https://orcid.org/0000-0002-6544-6113
- Ilyash A.V. – PhD Assist., Dept. of Urology and Human Reproductive Health (with the Pediatric Urology and Andrology Course), Rostov State Medical University; Rostov-on-Don, Russia; https://orcid.org/0000-0001-8433-8567
- Glukhov V.P. – PhD Assoc.Prof. (Docent); Assoc. Prof., Dept. of Urology and Human Reproductive Health (with the Pediatric Urology and Andrology Сourse), Rostov State Medical University; Rostov-on-Don, Russia; https://orcid.org/0000-0002-8486-9357
1125 Introduction. When diagnosing prostate cancer (PCa) in 20–40% of patients, more than one prostate biopsy (BP) is required. The incidence of PCa in recurrent BP is 20%.
Purpose of the study. To identify the differences in prostate cancer detected in primary and recurrent BP.
Materials and methods. The study included 44 patients with prostate cancer. Group I consisted of 19 men with PCa detected in recurrent BP (medians: age – 60 years, PSA – 9.9 ng / ml, prostate volume – 44.3 cm3 , tumor in biopsy – 15%). A lesion in the prostate, according to transrectal ultrasonography (TRUS), was detected in 26% of patients, PIN 3 – in 20%, cT1a – in 5.3%, cT1b – in 26.3%, T1c – in 21.0%, cT2 – at 47.4%. Group II included 25 men with prostate cancer detected in primary BP (medians: age – 63 years, PSA – 7.1 ng / ml, prostate volume – 38 cm3 , tumor in biopsy – 40%). A lesion in the prostate with TRUS was detected in 68% of patients, PIN 3 – in 20%, stage cT1c – in 76.0%, cT2 – in 24.0%. Radical prostatectomy was performed in 15 patients: 7 in group I and 8 in group II. After morphological studying of removed prostate in group I, stage pT2a was detected in 57.1% of patients, pT2b – in 14.3%, pT2c – in 28.6%, invasion of prostate cancer into the capsule of the gland – in 28.6%. Group ISUP-1 corresponded to 14% of patients, ISUP-2 – 43%, ISUP ≥ 3 – 43%. After evaluation of the drug in group II, stage pT2a was detected in 12.5% of patients, pT2c – in 87.5%, prostate cancer invasion into the glandular capsule – in 9%, ISUP ≥ 3 – in 100%.
Results. Comparison of the groups revealed differences in the volume of the tumor in the biopsy specimen (p = 0.005), the criterion for the involvement of the gland capsule in the tumor process (p = 0.007), the proportion of patients with a focus on TRUS (p = 0.01) with the prevalence of these signs in group II. The groups were comparable in pT stage, ISUP and lesion volume in the gland preparation (p> 0.05).
Conclusion. The low efficiency of primary PD is due to the shortcomings of its randomness and low accuracy. The absence of PCa in systemic PD is not a sign of a small tumor in the gland. Protate cancer detected during repeated PD is quite aggressive.
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