The study of the levels of sex hor­mones in 35 patients with varico­cele, underwent Marmar-Goldstein surgery, and 31 patients underwent surgery on the scrotum due to hydro­cele, inguinal hernia, as well as other pathology of testicles.
The levels of hormones (testosterone, estradiol, progesterone) were mea­sured in serum taken simultaneously from the cubital vein and the pampi­niform plexus vein.The highest level of sex hormones were observed in the veins of the pampiniform plexus in patients with varicocele, testosterone (1445.769 119.175 ng / ml) and estradiol (1528.519 137.238 pg / ml) levels were in more than 150 times higher than normal, concentration of pro­gesterone (6.484 0.935 ng / ml) was increased not so significantly.In the control group, increase of sex hormones level was not so signifi­cant - from sevenfold (progesterone) to 33 - fold (testosterone).The pathogenesis of varicocele as a hormone-dependent phlebopathy is discussed.
Stagnation of blood in the pampini­form venous plexus and increase of sexhormones level, especially estrogen and progesterone, on the first stage of the development of varicocele can cause hormone-dependent phlebopa- thy, able to undergo reverse develop­ment according to stabilization and reduction of sex hormones level.In patients with connective tissue dysplasia phlebopathy progresses into a phase of irreversible changes in the venous wall with a significant and persistent expansion of the lumen of the pampiniform plexus veins, which requires surgical intervention. Authors offer a method of assessment of varicocele severity and possibility of its recurrence by the level of hor­mones in the venous blood.