Contacts: Prosyannikov Mikchail Yurievich, prosyannikov@gmail.com

Introduction. Hypercalciuria (HCU) is one of the main metabolic lithogenic disorders caused urolithiasis. Considering the significant role of calcium in the pathogenesis of urolithiasis, the proven effect of HCU on the initiation of stone formation during urolithiasis, it was decided to study the effect of calciuria on the frequency of formation of urinary stones of various chemical composition.

Materials and methods.Material for the study results of the chemical composition analysis of 708 urinary calculi from 303 men and 405 women from the age of 16 to 78 years. The study was conducted retrospectively. All patients underwent an analysis of the chemical composition of urinary stone and a biochemical analysis of daily urine. Method of dividing the ranked variation series of calciuria into 10 ranges was used to assess the effect of the degree of calciuria on the frequency of calculi detection. Each range had from 64 to 75 observations.

Results and its discussion.HCU with an excretion level of more than 4.4 mmol/day increases the frequency of formation of calcium-oxalate stones by 20.4% (p=0.004). With an increase in the degree of calciuria in the ranges 3.1-3.76 to 9.0-14.8 mmol/day, the frequency of formation of calcium (oxalate-phosphate) stones is statistically significantly increased by 2.43 times (p<0.00005). Neither high nor low degree of calciuria had an effect on the frequency of formation of calcium phosphate (carbonatapatite) stones. Increased calciuria in the range from 3.0 to 14.8 mmol/day led to the decrease in the risk of struvite stone formation by more than 10 times (p<0.005). There is a marked decrease in the frequency of occurrence of urate stones by more than 19.3% of the total number of stones with an increase in calciuria in the ranges of 0.4-1.6 mmol/day to 5.2-6.03 mmol/day (p<0.0003).

Conclusion. HCU with an excretion level higher than 5.0 mmol/day should be considered as a factor leading to the formation of exclusively calciumoxalate stones, but not calcium-phosphate (carbonatapatite) urinary stones, in the genesis of which, as you know, other leading mechanisms are involved that are not directly related to HCU.

For citation: Prosyannikov M.Yu., Anokhin N.V., Golovanov S.A., Konstantinova O.V., Sivkov A.V., Apolikhin O.I. Influence of calciuria on the genesis of urine stones of various chemical composition. Experimental and clinical urology 2019; Experimental and clinical urology 2019;(3):100-103