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Mast cells in combination with depletion of testicular microbiome as a factor in the pathogenesis of non-obstructive male infertility DOI: 10.29188/2222-8543-2024-17-3-94-99
- Kulchenko N.G. – PhD, urologist, ultrasound diagnostics doctor, the associate professor at the department of Human Anatomy, medical faculty, Peoples Friendship University of Russia, Senior Researcher of the Scientific and Educational Resource Center for Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis of the Peoples’ Friendship University of Russia; Moscow, Russia; RSCI Author ID 543055, https://orcid.org/0000-0002-4468-3670
- Faniev M.V. – PhD, Associate Professor of the department of endoscopic urology of faculty of continuous medical education of medical institute of Peoples' Friendship University of Russia; Moscow, Russia; RSCI Author ID 1056145, https://orcid.org/0000-0002-7323-31260
- Kadyrov Z.A. – Dr. Sci., professor, head of dept. of endoscopic urology, Peoples' Friendship University of Russia; Moscow, Russia; RSCI Author ID 721133, https://orcid.org/0000-0002-1108-8138
- Atyakshin D.A. – PhD, head of the Scientific and Educational Resource Center for Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis of the Peoples’ Friendship University of Russia; Moscow, Russia; RSCI Author ID 264075, https://orcid.org/0000-0002-8347-4556
- Khanferyan R.A. – PhD, professor of Medical Institute of Peoples' Friendship University of Russia; Moscow, Russia; RSCI Author ID 77869, https://orcid.org/0000-0003-1178-7534
- Frantsev R.S. – PhD, Urologist, Associate Professor at the Department of Urology of the Stavropol State Medical University of the Ministry of Health of Russia; Stavropol, Russia; RSCI Author ID 844410, https://orcid.org/0009-0000-8893-7938
- Grigoryeva T.V. – PhD, Leading Researcher, Scientific Research Laboratory «Multimix Technologies of Living Systems», Kazan Federal University, Institute of Fundamental Medicine and Biology; Kazan, Russia; RSCI Author ID 616577; https://orcid.org/0000-0001-5314-7012
- Markelova M.I. – Researcher, Scientific Research Laboratory «Multimix Technologies of Living Systems», Kazan Federal University, Institute of Fundamental Medicine nd Biology; Kazan, Russia; RSCI Author ID 976359; https://orcid.org/0000-0001-7445-2091
47 Introduction. Male infertility is a complex disease with many potential causes, including hormonal imbalance, anatomical problems, genetic factors, lifestyle factors, and more. Currently, there is a fairly large group of infertile men with unspecified causes of the disease.
Clinical case. This clinical observation demonstrates a patient whose azoospermia was caused by an increase in the number of mast cells (MC) in the interstitial tissue of the testicle and depletion of the testicular microbiome. MC in the testicle, which are in close contact with the structures of the wall of the seminiferous tubule, contribute to dysfunction of the hematotesticular barrier.
Conclusion. An increase in mast cells in the testicular interstitium in men can have a negative effect on spermatogenesis. Using this clinical case, it was shown for the first time that an increase in the number of tryptase-positive cells in combination with depletion of the testicular microbiome contributes to the development of male infertility. However, the question of what signaling mechanisms facilitate this process requires further study.
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