Intratumoral heterogeneity of the parenchyma and stroma of bladder cancer
Introduction. The interaction of the tumor stroma and parenchyma with epithelial cells of bladder cancer (BCa) plays a crucial role in the course and progression of the disease. However, currently, there are no clearly defined markers reflecting the tumor microenvironment, which hinders the assessment of their impact on the course of BCa.
Objective. To analyze current understanding of the BCa microenvironment and identify immunohistochemical (IHC) markers of the tumor stroma and parenchyma.
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