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Number №3, 2021 - page 100-111

Actual possibilities of pathogenetic treatment of patients with with purine dismetabolism DOI: 10.29188/2222-8543-2021-14-3-100-110

For citation: Rudenko V.I., Demidko Yu.L., Krayev I.G. Actual possibilities of pathogenetic treatment of patients with with purine dismetabolism. Experimental and Clinical Urology, 2021;14(3):100-110; https://doi.org/10.29188/2222-8543-2021-14-3-100-110
Rudenko V.I., Demidko Yu.L., Kraev I.G.
Information about authors:
  • Rudenko V.I. – Dr. Sci., Professor, Head of the Department of X-ray Shockwave Remote Lithotripsy, Institute of Urology and Human Reproductive Health. Clinic of urology named after R.M. Fronshtein of Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Moscow, Russia; https://orcid.org/0000-0002-2081-8374
  • Demidko Yu.L. – Dr. Sci., Urologist of the Institute of Urology and Human Reproductive Health. Clinic of urology named after R.M. Fronshtein of Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Moscow, Russia; https://orcid.org/0000-0002-4231- 5524
  • Krayev I.G. – urologist, Medical hospital № 152 FMBA of Russia; Moscow, Russia
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Introduction. Purine dysmetabolism is occured by increased production of uric acid, which leads to hyperuricemia and hyperuricuria. The most common forms of purine metabolism disorders are the uratenephropathy, gout, and asymptomatic hyperuricemia.

Purpose. To evaluate the data published from 1992 to 2021 on the prevalence, forms of purine metabolism disorders, diagnostics and methods of their treatment. Two hundred and seventy original publications were identified, of which 37 were selected and analyzed.

Materials and methods. The search results in the scientific database PubMed, Web of Sciеnce, Sciеnce Direct were analyzed for the queries «urates», «gout», «uric acid», «purine metabolism», «hyperuricosuria», «treatment of urate nephrolithiasis», «luteolin; quercetin», «Smilax riparia».

Results. Urates are formed as a result of the metabolism of purine bases, two-thirds of which are excreted with urine. The most common form of purine dysmetabolism is urate nephrolithiasis, which accounts for up to 10% of all forms of kidney stone disease. The main risk factors include low urinary pH, decreased urine output and hyperuricosuria. Treatment options for such stones depend on the size, chemical composition, location, and concomitant diseases. The main methods of treatment are conservative therapy and surgical interventions.

Conclusions. Since the available conservative therapy may not be suitable for all patients, and surgical intervention carries certain risks, a unique herbal complex «Uralix®» was created to treat patients with urate stones in the kidneys and urinary tract. Its components luteolin, quercetin and sarsaparilla extract reduce uric acid levels and improve renal function in urate nephropathy.

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urates; gout; uric acid; purine metabolism; hyperuricosuria; treatment of urate nephrolithiasis; luteolin; quercetin; Smilax riparia

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