Contacts: Belousov Igor Ivanovich, belrost_dept@mail.ru

Introduction. Minipercutaneous nephrolithotripsy (mini-PNL) is a relatively new method of treating nephrolithiasis with stone sizes up to 20 mm. Determining its capabilities in treating larger kidney stones is of special interest. Studying the effect of mini-PNL on renal function will supplement the safety information of the method and may change the standard indications for its use. Materials and methods.Mini-PNL was performed in 62 patients with multiple, large single kidney stones and staghorn stones. The dynamics of creatinine, cystatin C, C-reactive protein, lipocalin associated with neutrophil gelatinase (NGAL) and interleukin-18 in the early postoperative period was studied. Non-parametric statistics were used for statistical processing of results (Statistica 10.2; StatSoft Inc., USA).

Results. The smallest systemic inflammatory response was observed in the treatment of multiple stones, the maximum – with mini-PNL of staghorn stones. The registered levels of the studied markers in the groups after the operation did not exceed the standard ones and were similar in concentration gradient. At the same time, more pronounced initial changes in renal function and the likelihood of predicting further development of damage to the renal function are greater in the treatment of multiple kidney stones.

Conclusion. The studied markers demonstrate the absence of significant variability in the groups; statistically significant correlations are determined between them. The highest initial degree of impaired renal function is observed in patients with multiple kidney stones. These data should be considered when planning treatment for this category of patients. Nevertheless, mini-PNL has a comparable effect on renal function in the treatment of stones of various physical properties, which expands the possibilities of using this method in the treatment of nephrolithiasis. Key words: nephrolithiasis, kidney stones, markers of kidney damage, minipercutaneous nephrolithotripsy, mini-PNL.

For citation: Belousov I.I., Sagakyants A.B., Kogan M.I., Trusov P.V. Safety of mini-PNL in treatment of staghorn stones, large singleand multiple kidney stones: monitoring markers of renal function. Experimental and clinical urology 2019;(3):92-99