Interaction of systemic and local homeostasis disturbances in patients with chronic abacterial prostatitis III-B (Experimental study)

Shormanov I.S., Mozhaev I.I., Sokolova H.A., Ryzhkov A.I., Shormanova N.S.

Aim is to study, compare and identify the possible interrelations between the homeostasis disorders of the systemic (blood) and organ (in the prostate gland)levelsin various experimental models of chronic abacterial prostatitis (CAP) III-B.

Material and methods. In the experiment 90 random adult healthy male rats weighing 180-200 grams were used, which were divided into 4 groups: control group (n = 30) and 3 basic groups of experimental modeling (group 1 (n = 20) – animals with experimental model of CAP, group 2 (n = 20) – animals with experimental model ofsystemic stress, group 3 (n = 20) – animals with combined experimental model of CAP and system stress. Peripheral blood (systemic level) and tissue homogenate (organ level) in which identical homeostatic indices of cytokine metabolism (IL8 and IL-10) and oxidative status (diene conjugates, malonic dialdehyde, catalase activity) were studied at all animals, and the parameters of the control group were taken as the conditional norm.

Results. In the CAP model it was shown that the most significant shifts in the studied homeostatic parameters were observed in the homogenate of the prostate gland and to a lesser extent in the systemic blood flow (p <0.05). These findings can reflect the early, initial (preclinical) stages of CAP III-B. In the model of systemic stress with initially intact prostate, the ability of a systemic stress reaction to trigger cytokine and oxidative disorders not only in the systemic blood stream but also in the homogenates of the prostate gland is shown. These findings allowed us to regard systemic stress as a possible pathogenetic systemic factor of CAP III-B. e combined model demonstrated the presence of reliable links between systemic and organ disorders of cytokine and oxidative homeostasis, which are prone not only to interaction, but also to mutual burdening.

Conclusions. Chronic abacterial prostatitis III-B can be considered as a local pathology of the prostate with mixed multifactorial pathogenesis, mediated by interaction and mutual burdening of systemic and organ homeostatic disorders. Taking into account the results of the experimental study in order to improve the results of treatment of CAP III-B, it is necessary to develop pathogenetic complex pharmacotherapy, directed simultaneously at the correction of all homeostatic disorders, both at the organ and systemic levels.

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chronic abacterial prostatitis (CAP) III-B, cytokines, stress, diene conjugates, malonic dialdehyde, catalase, pathogenesis, interrelation, systemic level, organ level

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