Sodium hypochlorite in regulation of renal tubular concentration function

Ivaschenko V.V., Danilkov A.P., Golovanov S.A., Kirpatovskiy V.I., Kudryavcev Yu.V., Drozhzheva V.V.

The paper is dedicated to study of mechanism of sodium hypochlorite effect on renal concentration function. In two experimental series we studied metabolism parameters and functional ability of kidneys of intact rats after parenteral administration of sodium hypochlorite (SH) solution and opportunities to enhance renal structural-functional tolerance to ischemia upon parenteral administration of 0,06% SH solution in preischemic period.

SH exerts true preventive and nephroprotective effects. Morphologically, upon administration of 0,06% sodium hypochlorite solution in pre-ischemic period two types of drug’s nephroprotective effect was observed. On the one hand alteration degree of renal tubular epithelium cells decreased, on the other hand progress and course of reparative (mesenchymal) inflammatory reaction accelerated. Nephroprotective effect was registered upon parental administration of sodium hypochlorite for 4 days in pre-ischemic period at dose of 2-3 mg/kg.

Course features of post-ischemic period in studied animal groups were analyzed. Tolerance to ischemia of kidneys by means of parenteral administration of 0,06% SH solution in pre-ischemic period was sufficient high. Rat survival on day 7 of post-ischemic period in the studied group was 80% while it was 33% in the control animal group. It was established an opportunity of parenteral administration of 0,06% SH solution as preventive and nephroprotective agent which improves cleaning and concentration function of nephron in energy deficit conditions.