The purpose of the study is to identify factors contributing to the progression of chronic kidney disease (CKD) in children with congenital malformations of the urinary system.

Metods. Study design - retrospective, observational, cohort. The study included 297 patients.

Resalts. All malformations of the kidneys were highly significant and reliable predictors of progression of CKD. Factor almost twice reduces the development of CKD was performing surgery, and the type of operation almost does not affect it, only its timeliness. Equally important was and adequate conservative treatment aimed at prevention of recurrence of pyelonephritis, the elimination of bacteriuria, adjust blood pressure and anemia.

Conclusion. The introduction into clinical practice of the above principles of treatment of CKD with obstructive uropathies allowed significantly (p=0,007) four times (Odds ratio- 0.25) to reduce the likelihood of progression of CKD in children treated malformations of the kidneys after 2000.

Author declare lack of the possible conflicts of interests.