Comparative efficacy of medical treatment in patients with voiding dysfunction after operation due to benign prostatic hyperplasia

Alchinbaev M.K., Abdil'manov K.M., Batyrbekov M.T., Mansurova I.B., Kuanshalieva Zh.E.

We present the results of medical therapy of post-operative overactive bladder symptoms in 76 patients who underwent the operation for benign prostatic hyperplasia. The first signs of bladder dysfunction were urgency, urinary incontinence and were found in patients mean in 1.5 months after operation. Urodynamic studies showed the presence of overactive bladder in patients.

All patients after the operation were divided into three groups. Patients of group 1 (n=25) received tolterodine 2 mg twice a day, patients of group 2 (n=25) received tamsulozin 0.4 mg once a day, patients of group 3 (n=26) received combination therapy with tolterodine 2 mg once a day and tamsulozin 0.4 mg once a day. The total length of the treatment was 3 months, interim results were obtained at 2 weeks and 1 month of treatment. Efficacy was estimated through the subjective estimation of the micturition by the patients and by the urodynamic criteria.

The most effective type of therapy was the combination therapy using tolterodine 2 mg once a day and tamsulozin 0.4 mg once a day; being on this therapy 65.3% presented with subjective improvement and significant improvement in urodynamic parameters.

Drawing a conclusion, it is reasonable to prescribe choline-blockers and alpha-blockers in patients immediately after operation due to prostate enlargement. This would efficiently prevent the overactive bladder symptoms to occur.

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