Metabolic syndrome, androgen deficiency and stress: estimation of the influence on the development of chronic kidney and hepatic disease in male white rats

Grekov E.A., Kirpatovskiy V.I., Golovanov S.A., Drozhzheva V.V., Kazachenko A.V.

In chronic experiments with 30 male white inbreed rats we have investigated the influence of high-calorie diet (addition of 20% margarine to the formula feed and 20% fructose to the water), androgen deficiency (bilateral orchiectomy) and stress (due to immobilisation) and their combination on the biochemical markers of kidneys and liver function. It was shown that negative influence was maximal for liver and kidneys in case of 3-months high-calorie diet resulting in changes which were typical for metabolic syndrome (hyperglycemia, hypertriglyceridemia, hypercholesterolemia, hyperenzymemia) and in the decrease of glomerular filtration rate and increase in enzymuria.

Androgen deficiency also led to decrease in the filtration rate (decrease in glomerular filtration) and amplificated catabolic reactions, resulting in hypoproteinemia, hypertriglyceridemia and high uric acid blood concentration. Stress led to the disturbance of electrolytes reabsorption in renal tubules and to hyperglycemia, probably due to the excessive release of stress hormones, and to disturbances in lipid metabolism (increase in cholesterol, triglycerides and low-density lipoproteins level), leading to deterioration of hepatic function.

Combination of these 3 factors led to the worst changes in the biochemical parameters in charge of liver and kidney function because of the negative influence accumulation.

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