Номер №3, 2018 - page 34-41

Urolithiasis and cardiovascular diseases: only a statistical link or a common pathogenetic mechanism?

Prosyannikov M.Yu., Anohin N.V., Golovanov S.A., Kirpatovskiy V.I., Sivkov A.V., Konstantinova O.V., Ivanov K.V., Apolihin O.I.
Information about authors:
  • Prosiannikov M.Ю. – PhD, Head of Department of urolithiasis of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation, e-mail: prosyannikov@gmail.com
  • Anokhin N.V. – PhD, Researcher at the Department of urolithiasis of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation, e-mail: anokhinnikolay@yandex.ru
  • Golovanov S.A. – Dr.Sc., head of group of clinical laboratory diagnostic of Scientific Laboratory Department of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation, e-mail: sergeygol124@mail.ru
  • Kirpatovskiy V.I. – Dr. Sc., Chief Researcher at the Scientific Laboratory Department of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation, e-mail: vladkirp@yandex.ru
  • Sivkov A.V. – PhD, assistant director of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation, e-mail: uroinfo@yandex.ru
  • Konstantinova O.V – Dr. Sc., Chief Researcher at the Department of urolithiasis of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation, e-mail: konstant-ov@yandex.ru
  • Ivanov K.V. – resident of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation
  • Apolikhin O.I. – Dr. Sc., professor, corresponding member of the Russian Academy of Sciences. Director of N.A. Lopatkin. Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation, e-mail: apolikhin.oleg@gmail.com

The pathogenesis of urolithiasis, as well as atherosclerosis, is not fully understood. According to hypothesis, the start point of lithogenesis or atherogenesis is endothelial wall damage. It is possible that free radical oxidation is part of the pathogenesis of both diseases. In addition, the results of a large number research works, assert that urolithiasis patients are more likely to get sick atherosclerosis.

Atherosclerosis and urolithiasis are considered as comorbid states - diseases with a single pathogenetic mechanism. Furthermore, some researchers refer urolithiasis to the group of systemic diseases. There are urolithiasis pathogenetic connection with atherosclerosis, diabetes mellitus, essential hypertension, metabolic syndrome, myocardial infarction, stroke.

There are results of numerous research works, urolithiasis and atherosclerosis common links of pathogenesis, possible treatment options in this review article.

Authors declare lack of the possible conflicts of interests.

AttachmentSize
Download538.96 KB
urolithiasis, atherosclerosis, lipid peroxidation, free radicals, comorbid states

Readera - Социальная платформа публикаций