Urolithiasis and cardiovascular diseases: only a statistical link or a common pathogenetic mechanism?

Prosyannikov M.Yu., Anohin N.V., Golovanov S.A., Kirpatovskiy V.I., Sivkov A.V., Konstantinova O.V., Ivanov K.V., Apolihin O.I.

The pathogenesis of urolithiasis, as well as atherosclerosis, is not fully understood. According to hypothesis, the start point of lithogenesis or atherogenesis is endothelial wall damage. It is possible that free radical oxidation is part of the pathogenesis of both diseases. In addition, the results of a large number research works, assert that urolithiasis patients are more likely to get sick atherosclerosis.

Atherosclerosis and urolithiasis are considered as comorbid states - diseases with a single pathogenetic mechanism. Furthermore, some researchers refer urolithiasis to the group of systemic diseases. There are urolithiasis pathogenetic connection with atherosclerosis, diabetes mellitus, essential hypertension, metabolic syndrome, myocardial infarction, stroke.

There are results of numerous research works, urolithiasis and atherosclerosis common links of pathogenesis, possible treatment options in this review article.

Authors declare lack of the possible conflicts of interests.

AttachmentSize
Download538.96 KB
urolithiasis, atherosclerosis, lipid peroxidation, free radicals, comorbid states

Readera - Социальная платформа публикаций