Яровой С.К.

Introduction. While providing urological care to patients suffering with nephrolithiasis, prior attention is to be paid to choosing the appropriate surgical approach. Assessment of risk for commorbidities such as coronary artery disease (CAD) should affect the choice of surgical technique. The treatment tactics for such comorbid patients have not been sufficiently developed and are poorly covered in the scientific literature. An appropriate choice of surgical technique is not presented.

Data of 414 patients with scrotal and testicular trauma who were treated by Moscow emergency andrology service in 2008-2017 is presented in this paper.

There was a trend towards uncomplicated course and organ preservation in group of patientswho underwent urgentsurgical intervention when compared to patients who were managed conservatively. In nonsurgical group there was a significantly higher incidence of orchitis when compared to surgically treated patients.

The paper presents the analysis of the up-to-date literature related to the diagnostics and emergency management of testicular trauma. The diagnosticsis based on physical examination of the patient and ultrasound scanning of the organ injured. In case of testiculartrauma, the sensitivity and specificity of scanning were 66.7% and 75%, respectively.

The paper describes and analyses iatrogenic penile skin necrosis in a patient, who underwent operative treatment of penile fracture. Presumably, penile skin necrosis was accounted by severe impairment of blood circulation, which is due to inadequate choice of access to the cavernous bodies.

A patient with subtotal ischemic penile skin necrosis recurrently asked for medical help. The absence of infectious and inflammatory complications accounted for the choice of the method of operative intervention, which was the urgent revision of the penis, necrectomy, Reich surgery)

The article analyzes the results of application of three schemes of induction immunosuppressive therapy with the use of different drugs ofpoly- and monoclonal antibodies in patients after relative-to-relative transplantation of the kidney.

The aim of the study was to investigate the role of the co-morbidities (androgen deficiency, ischemic heart disease, diabetes mellitus type 2) in the pathogenesis of the secondary changes in the bone skeleton during the different forms of nephrolithiasis. The study included 193 patients from Clinical Hospital 47 (Moscow, Russia) and National Scientific Institute of Urology (Moscow, Russia). The decreases in the testosterone concentration affected negatively the mineral density of the bone tissue in patients with nephrolithiasis independent on causality.

In this article we have analyzed the data from the international literature related to the treatment of the osseous metabolic damage because of the recurrent nephrolithiasis. Main groups of medications are outlined, which are indicated for use in this situation: vitamin D and its active metabolites, citrates and thiazides bisphosphonates.

Pharmacodynamic and pharmacokinetic properties of the fosfomycin along with the spectrum of its antimicrobial activity are discussed in this article with regard to the available evidence database. Fosfomycin is supplied to the market in 2 forms (fosfomycin trometamol) parenteral (fosfomycin sodium), which show the substantial differences in pharmacological features and are indicated in different conditions. Fosfomycin trometamol mainly in patients with acute cystitis.

In this article the main clinical scenarios of the purine metabolism (PM) disorders, which could be the case in urological practice, are described. Also a reference to the pathogenesis is given shortly.

E.N. Kareva, S.K. Jarovoiy, N.G. Moskaleva, N.S. Aleksandrov, D.A. Tihonov